In the Treasure room some examples of silverware coming from major Italian cities and used for the liturgy and for the worship of saints are kept.

An ostensory and a Reliquary casket comes from Naples (1480). A silver sculpture is also kept belonging to Neapolitan art, representing Saint Michael who strikes down the devil. Other artworks originating from Naples are also present such as a ciborium (1720), a chalice (1719), a vase-shaped reliquary, two precious shining ostensories (1780), a chalice with cherubs (19th century) and processional tortilic cross (1701).

The group of processional crosses from the 15th century and the copper and silver adorned Reliquary casket were made in Sulmona.

There are some crosses made of amber and crystal and a pastoral scroll from Northern Italy. The censer dating back to the 1500s was made in Tuscany, whereas the 16th century Reliquary cross with four sphinxes at its base is attributed to Roman Mannerism. The reliquary (1734) and two aspersoriums with gem inserts used in chapels or for private worship were made in Rome.

There are a few works from important schools for goldsmiths in Sicily. There is a ciborium, a radial ostensory and an ex vote with Saint Rosalia from the 17th century. The reliquary of Saint Benedict and the chalice in filigrane dating back to the 1700s were made in Messina. Whereas there are two altar cards with the half length portraits of Benedict and Scholastica.

There are other examples of silverware kept in the Museum collection of which we can find the Juvarra chalice (1700), the Acheropita from the 15th century, the papal rings from the 15th century, and also clasps, ampules, aquamaniles and chandeliers.
There is a censer with the symbols of the Passion (16th century), a late-baroque style navicula and bucket among the Genovese silverware.